human ASCC3 shRNA silencing Adenovirus

Name 
Ad-h-ASCC3-shRNA
Cat No 
shADV-201541
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ASCC3.

shADV-201541
Ad-h-ASCC3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ASCC3 (activating signal cointegrator 1 complex subunit 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
activating signal cointegrator 1 complex subunit 3; ASC-1 complex subunit P200; ASC1p200; HELIC1; helicase, ATP binding 1; RNA helicase family; RNAH; trip4 complex subunit p200
Description (eCommerce)
Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a 3'-5' DNA helicase involved in repair of alkylated DNA. ASCC3 promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. ASCC3 also enhances NF-kappa-B, SRF and AP1 transactivation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y3R0].
Gene ID
10973
Gene Name (eCommerce)
activating signal cointegrator 1 complex subunit 3
Gene Name (Vector)
activating signal cointegrator 1 complex subunit 3
Gene Symbol
ASCC3
HGNC ID
HGNC:18697
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
6606
ORF Size (bp)
6606 bp
Protein Name (eCommerce)
Activating signal cointegrator 1 complex subunit 3
RefSeq ID
NM_006828
RefSeq Synonyms
NM_022091, NM_006828, NM_001284271, BC150215, BC050681,
Research Areas
DNA Damage/Repair,Helicase Activity,Transcription Factor/Regulator
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a 3'-5' DNA helicase involved in repair of alkylated DNA. ASCC3 promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. ASCC3 also enhances NF-kappa-B, SRF and AP1 transactivation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y3R0].
UniGene ID
Hs.486031
UniProt ID (eCommerce)
Q8N3C0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.