human ARHGEF2 shRNA silencing Adenovirus

Name 
Ad-h-ARHGEF2-shRNA
Cat No 
shADV-201363
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ARHGEF2.

shADV-201363
Ad-h-ARHGEF2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
GEF; GEFH1; GEF-H1; guanine nucleotide exchange factor H1; LFP40; microtubule-regulated Rho-GEF; NEDMHM; P40; proliferating cell nucleolar antigen p40; rho guanine nucleotide exchange factor 2; Rho/Rac guanine nucleotide exchange factor (GEF) 2
Description (eCommerce)
GEF-H1 (guanine nucleotide exchange factor H1) is a microtubule regulated guanine nucleotide exchange factor for the RhoA GTPase. It catalyzes the exchange of GDP for GTP by Rho in response to microtubule destabilization. GEF-H1 has shown to be regulated during cytokinesis and plays a role in the cleavage furrow.
Description (Vector)
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
9181
Gene Name (eCommerce)
Rho/Rac guanine nucleotide exchange factor 2
Gene Name (Vector)
Rho/Rac guanine nucleotide exchange factor 2
Gene Symbol
ARHGEF2
HGNC ID
HGNC:682
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2880
ORF Size (bp)
2880 bp
Protein Name (eCommerce)
Rho guanine nucleotide exchange factor 2
RefSeq ID
NM_004723
RefSeq Synonyms
NM_004723, NM_001162384, NM_001162383, BC020567,
Research Areas
Apoptosis,Cell Cycle,Cell Division,Cytoskeleton,Golgi Apparatus,GPCR Signaling,Immunology,Innate Immunity,Neurobiology,Neurodevelopment,Neurogenesis,NGF Signaling,Rho Signaling,Signal Transduction,T-cell Receptor Signaling,Zinc-finger
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
GEF-H1 (guanine nucleotide exchange factor H1) is a microtubule regulated guanine nucleotide exchange factor for the RhoA GTPase. It catalyzes the exchange of GDP for GTP by Rho in response to microtubule destabilization. GEF-H1 has shown to be regulated during cytokinesis and plays a role in the cleavage furrow.
UniGene ID
Hs.655209
UniProt ID (eCommerce)
Q92974

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.