human ARHGAP1 shRNA silencing Adenovirus

Name 
Ad-h-ARHGAP1-shRNA
Cat No 
shADV-201303
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ARHGAP1.

shADV-201303
Ad-h-ARHGAP1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ARHGAP1 (Rho GTPase activating protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CDC42 GTPase-activating protein; CDC42GAP; GTPase-activating protein rhoGAP; GTPase-activating protein rhoOGAP; GTPase-activating protein, Rho, 1; p50rhoGAP; p50-RhoGAP; rho GTPase-activating protein 1; RHOGAP; RHOGAP1; rho-related small GTPase protein activator; rho-type GTPase-activating protein 1
Description (eCommerce)
Cdc42 GTPase-activating protein (Cdc42GAP) is also known as p50RhoGAP and ARHGAP1. Cdc42GAP functions as a negative regulator of the Rho GTPase, Cdc42, by catalyzing the hydrolysis of GTP to GDP by Cdc42. Cdc42 activity is proposed to be involved in multiple cellular activities such as motility, survival, and genomic stability.
Description (Vector)
ARHGAP1 encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members.
Gene ID
392
Gene Name (eCommerce)
Rho GTPase activating protein 1
Gene Name (Vector)
Rho GTPase activating protein 1
Gene Symbol
ARHGAP1
HGNC ID
HGNC:673
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1320
ORF Size (bp)
1320 bp
Protein Name (eCommerce)
Rho GTPase-activating protein 1
RefSeq ID
NM_004308
RefSeq Synonyms
NM_004308, BC018118,
Research Areas
Aging,Immunology,RAC1 Signaling,Rho Signaling,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
cell_biology,immunology,signal_transduction
Species
human
Target Sentence
Cdc42 GTPase-activating protein (Cdc42GAP) is also known as p50RhoGAP and ARHGAP1. Cdc42GAP functions as a negative regulator of the Rho GTPase, Cdc42, by catalyzing the hydrolysis of GTP to GDP by Cdc42. Cdc42 activity is proposed to be involved in multiple cellular activities such as motility, survival, and genomic stability.
UniGene ID
Hs.138860
UniProt ID (eCommerce)
Q07960

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.