human ADAMTS13 shRNA silencing Adenovirus

Name 
Ad-h-ADAMTS13-shRNA
Cat No 
shADV-200379
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ADAMTS13.

shADV-200379
Ad-h-ADAMTS13-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ADAMTS13 (ADAM metallopeptidase with thrombospondin type 1 motif 13). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
A disintegrin and metalloproteinase with thrombospondin motifs 13; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13; ADAM-TS 13; ADAM-TS13; ADAMTS-13; C9orf8; von Willebrand factor-cleaving protease; vWF-cleaving protease; VWFCP; vWF-CP
Description (eCommerce)
ADAMTS13 is part of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family that is responsible for cleaving von Willebrand Factor (vWF). ADAMTS13 is synthesized in the liver and secreted to the plasma. A deficiency of the ADAMTS13 protease activity results in unusually larger multimers of vWF and is associated with thrombotic thrombocytopenic purpura.
Description (Vector)
ADAMTS13 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
Gene ID
11093
Gene Name (eCommerce)
ADAM metallopeptidase with thrombospondin type 1 motif 13
Gene Name (Vector)
ADAM metallopeptidase with thrombospondin type 1 motif 13
Gene Symbol
ADAMTS13
HGNC ID
HGNC:1366
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4284
ORF Size (bp)
4284 bp
Protein Name (eCommerce)
A disintegrin and metalloproteinase with thrombospondin motifs 13
RefSeq ID
NM_139025
RefSeq Synonyms
NM_139027, NM_139026, NM_139025, BC172369,
Research Areas
Cancer,IFN Signaling,Interleukin Signaling,Metabolism/Metabolic Process,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,immunology,metabolism,signal_transduction
Species
human
Target Sentence
ADAMTS13 is part of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family that is responsible for cleaving von Willebrand Factor (vWF). ADAMTS13 is synthesized in the liver and secreted to the plasma. A deficiency of the ADAMTS13 protease activity results in unusually larger multimers of vWF and is associated with thrombotic thrombocytopenic purpura.
UniGene ID
Hs.131433
UniProt ID (eCommerce)
Q76LX8

Recently Viewed Products

Ad-r-TNP1

Cat No: ADV-290935

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.