rat MGC114529 shRNA silencing AAV

Name
AAV-r-MGC114529-shRNA

Cat No
shAAV-293958

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Rat Magec2.

shAAV-293958

AAV-r-MGC114529-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Magec2 (MAGE family member C2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.

Gene ID

317590

Gene Name (Vector)

MAGE family member C2

Gene Symbol

Magec2

ORF Size (aa)

1290

ORF Size (bp)

1290 bp

RefSeq ID

NM_001025713

RefSeq Synonyms

NM_001025713, BC097464,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.