rat SNF8 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Snf8.
shAAV-293848
AAV-r-SNF8-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Snf8 (SNF8, ESCRT-II complex subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
D11moh34; RGD1310144
Description (Vector)
Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4.
Gene ID
287645
Gene Name (Vector)
SNF8, ESCRT-II complex subunit
Gene Symbol
Snf8
ORF Size (aa)
777
ORF Size (bp)
777 bp
RefSeq ID
NM_001007804
RefSeq Synonyms
NM_001007804, BC086364,
Species
rat
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.