rat NR1H4 shRNA silencing AAV

Name
AAV-r-NR1H4-shRNA

Cat No
shAAV-293596

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Rat Nr1h4.

shAAV-293596

AAV-r-NR1H4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Nr1h4 (nuclear receptor subfamily 1, group H, member 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Fxr

Description (Vector)

Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.

Gene ID

60351

Gene Name (Vector)

nuclear receptor subfamily 1, group H, member 4

Gene Symbol

Nr1h4

ORF Size (aa)

1452

ORF Size (bp)

1452 bp

RefSeq ID

NM_021745

RefSeq Synonyms

NM_021745, BC083815,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.