rat BDNF shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Bdnf.
shAAV-292605
AAV-r-BDNF-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Bdnf (brain-derived neurotrophic factor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Gene ID
24225
Gene Name (Vector)
brain-derived neurotrophic factor
Gene Symbol
Bdnf
ORF Size (aa)
750
ORF Size (bp)
750 bp
RefSeq ID
NM_001270630
RefSeq Synonyms
NM_012513, NM_001270638, NM_001270637, NM_001270636, NM_001270635, NM_001270634, NM_001270633, NM_001270632, NM_001270631, NM_001270630, BC087634,
Species
rat
Related Citations
- High salt loading increases brain derived neurotrophic factor in supraoptic vasopressin neurones. Balapattabi K, etc, (2018), Kirthikaa Balapattabi
- High Salt Intake Increases Blood Pressure via BDNF-Mediated Downregulation of KCC2 and Impaired Baroreflex Inhibition of Vasopressin Neurons. Katrina Y. Choe, etc, (2015), Neuron
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.