rat HOPX shRNA silencing AAV

Name
AAV-r-HOPX-shRNA

Cat No
shAAV-292117

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Rat Hopx.

shAAV-292117

AAV-r-HOPX-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Hopx (HOP homeobox). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GIIg15b; Hod; Obl

Description (Vector)

Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor.

Gene ID

171160

Gene Name (Vector)

HOP homeobox

Gene Symbol

Hopx

ORF Size (aa)

222

ORF Size (bp)

222 bp

RefSeq ID

NM_133621

RefSeq Synonyms

NM_133621, BC070950,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.