rat MICAL3 shRNA silencing AAV

Cat. No: shAAV-291104

Availability: 6-8 weeks

Name: AAV-r-MICAL3-shRNA

This is an AAV expressing shRNA for silencing of Rat Mical3.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Rat
Gene Symbol: Mical3
Gene Name: microtubule associated monoxygenase, calponin and LIM domain containing 3
Gene ID: 362427
ORF Size: 996 bp
RefSeq#: NM_001191085
Gene Description: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process.