rat NR2C1 shRNA silencing AAV

Name
AAV-r-NR2C1-shRNA

Cat No
shAAV-290463

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Rat Nr2c1.

shAAV-290463

AAV-r-NR2C1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Rat Nr2c1 (nuclear receptor subfamily 2, group C, member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Psg4; Tr2; TR2-11

Description (Vector)

Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.

Gene ID

252924

Gene Name (Vector)

nuclear receptor subfamily 2, group C, member 1

Gene Symbol

Nr2c1

ORF Size (aa)

1773

ORF Size (bp)

1773 bp

RefSeq ID

NM_145780

RefSeq Synonyms

NM_145780, BC061822,

Species

rat

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.