mouse NLRX1 shRNA silencing AAV

Name
AAV-m-NLRX1-shRNA

Cat No
shAAV-280918

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Nlrx1.

shAAV-280918

AAV-m-NLRX1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Nlrx1 (NLR family member X1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BC034204; NOD9

Description (Vector)

Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).

Gene ID

270151

Gene Name (Vector)

NLR family member X1

Gene Symbol

Nlrx1

ORF Size (aa)

2928

ORF Size (bp)

2928 bp

RefSeq ID

NM_178420

RefSeq Synonyms

NM_178420, NM_001163743, NM_001163742, BC050054,

Species

mouse

UniGene ID

Mm.3957

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.