mouse ITGA4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Itga4.
shAAV-280827
AAV-m-ITGA4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Itga4 (integrin alpha 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD49D; Itga4B
Description (Vector)
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
Gene ID
16401
Gene Name (Vector)
integrin alpha 4
Gene Symbol
Itga4
ORF Size (aa)
3099
ORF Size (bp)
3099 bp
RefSeq ID
NM_010576
RefSeq Synonyms
NM_010576, BC068313,
Species
mouse
UniGene ID
Mm.31903
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.