mouse DTX3L shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Dtx3l.
shAAV-280695
AAV-m-DTX3L-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Dtx3l (deltex 3-like, E3 ubiquitin ligase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AU042200; BC023741
Description (Vector)
Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation.
Gene ID
209200
Gene Name (Vector)
deltex 3-like, E3 ubiquitin ligase
Gene Symbol
Dtx3l
ORF Size (aa)
2076
ORF Size (bp)
2076 bp
RefSeq ID
NM_001013371
RefSeq Synonyms
NM_001013371, BC137694, BC085093,
Species
mouse
UniGene ID
Mm.390852
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.