mouse ZIC2 shRNA silencing AAV

Name
AAV-m-ZIC2-shRNA

Cat No
shAAV-277065

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Zic2.

shAAV-277065

AAV-m-ZIC2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Zic2 (zinc finger protein of the cerebellum 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HPE5; Ku

Description (Vector)

Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.

Gene ID

22772

Gene Name (Vector)

zinc finger protein of the cerebellum 2

Gene Symbol

Zic2

ORF Size (aa)

1587

ORF Size (bp)

1587 bp

RefSeq ID

NM_009574

RefSeq Synonyms

NM_009574, BC156493,

Species

mouse

UniGene ID

Mm.308936

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.