mouse ZBP1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Zbp1.
shAAV-276503
AAV-m-ZBP1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Zbp1 (Z-DNA binding protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2010010H03Rik; Dai; Dlm1; mZaDLM
Description (Vector)
Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity).
Gene ID
58203
Gene Name (Vector)
Z-DNA binding protein 1
Gene Symbol
Zbp1
ORF Size (aa)
1236
ORF Size (bp)
1236 bp
RefSeq ID
NM_021394
RefSeq Synonyms
NM_021394, NM_001139519, BC020033,
Species
mouse
UniGene ID
Mm.116687
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.