mouse XRCC4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Xrcc4.
shAAV-276421
AAV-m-XRCC4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Xrcc4 (X-ray repair complementing defective repair in Chinese hamster cells 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2310057B22Rik; AW413319; AW545101
Description (Vector)
Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV (LIG4). The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.
Gene ID
108138
Gene Name (Vector)
X-ray repair complementing defective repair in Chinese hamster cells 4
Gene Symbol
Xrcc4
ORF Size (aa)
981
ORF Size (bp)
981 bp
RefSeq ID
NM_028012
RefSeq Synonyms
NM_028012, BC025538,
Species
mouse
UniGene ID
Mm.37531
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.