mouse UBE2W shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ube2w.
shAAV-275509
AAV-m-UBE2W-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ube2w (ubiquitin-conjugating enzyme E2W (putative)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
6130401J04Rik
Description (Vector)
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination.
Gene ID
66799
Gene Name (Vector)
ubiquitin-conjugating enzyme E2W (putative)
Gene Symbol
Ube2w
ORF Size (aa)
456
ORF Size (bp)
456 bp
RefSeq ID
NM_025773
RefSeq Synonyms
NM_025773, NM_001271017, NM_001271016, BC020124,
Species
mouse
UniGene ID
Mm.122430
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.