mouse UBE2A shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ube2a.
shAAV-275460
AAV-m-UBE2A-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ube2a (ubiquitin-conjugating enzyme E2A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HHR6A; HR6A; Mhr6a
Description (Vector)
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.
Gene ID
22209
Gene Name (Vector)
ubiquitin-conjugating enzyme E2A
Gene Symbol
Ube2a
ORF Size (aa)
459
ORF Size (bp)
459 bp
RefSeq ID
NM_019668
RefSeq Synonyms
NM_019668, NM_001313696, BC026053,
Species
mouse
UniGene ID
Mm.395649
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.