mouse TSHZ3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Tshz3.
shAAV-275149
AAV-m-TSHZ3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Tshz3 (teashirt zinc finger family member 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
A630038G13Rik; mKIAA1474; teashirt3; Tsh3; Zfp537
Description (Vector)
Transcriptional regulator involved in developmental processes. Function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Regulates the development of neurons involved in both respiratory rhythm and airflow control. Promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. Involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes. Involved in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.
Gene ID
243931
Gene Name (Vector)
teashirt zinc finger family member 3
Gene Symbol
Tshz3
ORF Size (aa)
3246
ORF Size (bp)
3246 bp
RefSeq ID
NM_172298
RefSeq Synonyms
NM_172298, BC150674,
Species
mouse
UniGene ID
Mm.44141
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.