mouse TSC2 shRNA silencing AAV

Name 
AAV-m-TSC2-shRNA
Cat No 
shAAV-275120
Availability
Immediate
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Tsc2.

shAAV-275120
AAV-m-TSC2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Tsc2 (tuberous sclerosis 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Nafld; Tcs2
Description (Vector)
In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.
Gene ID
22084
Gene Name (Vector)
tuberous sclerosis 2
Gene Symbol
Tsc2
ORF Size (aa)
5229
ORF Size (bp)
5229 bp
RefSeq ID
NM_011647
RefSeq Synonyms
NM_011647, NM_001286720, NM_001286718, NM_001286716, NM_001286714, NM_001286713, NM_001039363, BC060701, BC052449,
Species
mouse
UniGene ID
Mm.30435

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.