mouse C3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse C3.
shAAV-274727
AAV-m-C3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse C3 (complement component 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI255234; ASP; HSE-MSF; Plp
Description (Vector)
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates|Function: Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
Gene ID
12266
Gene Name (Vector)
complement component 3
Gene Symbol
C3
ORF Size (aa)
4992
ORF Size (bp)
4992 bp
RefSeq ID
NM_009778
RefSeq Synonyms
NM_009778, BC043338,
Species
mouse
UniGene ID
Mm.19131
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.