mouse TMEM173 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Tmem173.
shAAV-274453
AAV-m-TMEM173-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Tmem173 (transmembrane protein 173). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2610307O08Rik; ERIS; Mita; MPYS; STING
Description (Vector)
Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Gene ID
72512
Gene Name (Vector)
transmembrane protein 173
Gene Symbol
Tmem173
ORF Size (aa)
1137
ORF Size (bp)
1137 bp
RefSeq ID
NM_028261
RefSeq Synonyms
NM_028261, NM_001289592, NM_001289591, BC046640,
Species
mouse
UniGene ID
Mm.45995
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.