mouse TERT shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Tert.
shAAV-274038
AAV-m-TERT-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Tert (telomerase reverse transcriptase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
EST2; TCS1; TP2; TR; TRT
Description (Vector)
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
Gene ID
21752
Gene Name (Vector)
telomerase reverse transcriptase
Gene Symbol
Tert
ORF Size (aa)
1755
ORF Size (bp)
1755 bp
RefSeq ID
NM_009354
RefSeq Synonyms
NM_009354, BC127068,
Species
mouse
UniGene ID
Mm.10109
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.