mouse STAT2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Stat2.
shAAV-273294
AAV-m-STAT2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Stat2 (signal transducer and activator of transcription 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1600010G07Rik; AW496480
Description (Vector)
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
Gene ID
20847
Gene Name (Vector)
signal transducer and activator of transcription 2
Gene Symbol
Stat2
ORF Size (aa)
2769
ORF Size (bp)
2769 bp
RefSeq ID
NM_019963
RefSeq Synonyms
NM_019963, BC167243,
Species
mouse
UniGene ID
Mm.471333
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.