mouse SMAD2 shRNA silencing AAV

Name 
AAV-m-SMAD2-shRNA
Cat No 
shAAV-272599
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse Smad2.

shAAV-272599
AAV-m-SMAD2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Smad2 (SMAD family member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
7120426M23Rik; Madh2; Madr2; mMad2; Smad-2
Description (Vector)
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Gene ID
17126
Gene Name (Vector)
SMAD family member 2
Gene Symbol
Smad2
ORF Size (aa)
1404
ORF Size (bp)
1404 bp
RefSeq ID
NM_010754
RefSeq Synonyms
NM_010754, NM_001311070, NM_001252481, BC089184, BC021342,
Species
mouse
UniGene ID
Mm.391091

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.