mouse ROS1 shRNA silencing AAV

Name
AAV-m-ROS1-shRNA

Cat No
shAAV-270793

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Ros1.

shAAV-270793

AAV-m-ROS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Ros1 (Ros1 proto-oncogene). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

c-ros; Ros-1

Description (Vector)

Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.

Gene ID

19886

Gene Name (Vector)

Ros1 proto-oncogene

Gene Symbol

Ros1

ORF Size (aa)

7020

ORF Size (bp)

7020 bp

RefSeq ID

NM_011282

RefSeq Synonyms

NM_011282, BC156297,

Species

mouse

UniGene ID

Mm.236163

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.