mouse RNF146 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Rnf146.
shAAV-270699
AAV-m-RNF146-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Rnf146 (ring finger protein 146). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2610509H23Rik; Iduna
Description (Vector)
E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of poly-ADP-ribosylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate poly-ADP-ribosylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent poly-ADP-ribosylated proteins via its WWE domain and mediates their ubiquitination.
Gene ID
68031
Gene Name (Vector)
ring finger protein 146
Gene Symbol
Rnf146
ORF Size (aa)
1080
ORF Size (bp)
1080 bp
RefSeq ID
NM_026518
RefSeq Synonyms
NM_026518, NM_001284279, NM_001110198, NM_001110197, NM_001110196, BC050795,
Species
mouse
UniGene ID
Mm.475694
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.