mouse REST shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Rest.
shAAV-270409
AAV-m-REST-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Rest (RE1-silencing transcription factor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2610008J04Rik; AA407358; NRSF; REST4
Description (Vector)
Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.
Gene ID
19712
Gene Name (Vector)
RE1-silencing transcription factor
Gene Symbol
Rest
ORF Size (aa)
3249
ORF Size (bp)
3249 bp
RefSeq ID
NM_011263
RefSeq Synonyms
NM_011263, BC127065,
Species
mouse
UniGene ID
Mm.392264
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.