mouse RASGRP2 shRNA silencing AAV

Name
AAV-m-RASGRP2-shRNA

Cat No
shAAV-270175

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Rasgrp2.

shAAV-270175

AAV-m-RASGRP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Rasgrp2 (RAS, guanyl releasing protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Caldaggef1; CDC25L

Description (Vector)

Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.

Gene ID

19395

Gene Name (Vector)

RAS, guanyl releasing protein 2

Gene Symbol

Rasgrp2

ORF Size (aa)

1824

ORF Size (bp)

1824 bp

RefSeq ID

NM_011242

RefSeq Synonyms

NM_011242, BC148631,

Species

mouse

UniGene ID

Mm.77017

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.