mouse RALA shRNA silencing AAV

Cat. No: shAAV-270091

Availability: 4-5 weeks

Name: AAV-m-RALA-shRNA

This is an AAV expressing shRNA for silencing of Mouse Rala.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Rala
Gene Name: v-ral simian leukemia viral oncogene A (ras related)
Gene ID: 56044
Gene Synonyms: 3010001O15Rik; AW322615; Ral; Rasl1
ORF Size: 621 bp
RefSeq#: NM_019491
Gene Description: Multifuntional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.
UniGene ID: Mm.27348