mouse PUS10 shRNA silencing AAV

Name
AAV-m-PUS10-shRNA

Cat No
shAAV-269862

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Pus10.

shAAV-269862

AAV-m-PUS10-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Pus10 (pseudouridylate synthase 10). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

2810013G11Rik; 4933435A13Rik; AU014648; C77560; Ccdc139

Description (Vector)

Pseudouridylate synthases catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. PUS10 catalyzes the formation of the universal psi55 in the GC loop of transfer RNAs (Probable). Modulator of TRAIL-induced cell death via activation of procaspase 8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death.

Gene ID

74467

Gene Name (Vector)

pseudouridylate synthase 10

Gene Symbol

Pus10

ORF Size (aa)

1584

ORF Size (bp)

1584 bp

RefSeq ID

NM_028956

RefSeq Synonyms

NM_028956, NM_028304, NM_001033654, BC025555,

Species

mouse

UniGene ID

Mm.29536

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.