mouse PTGDS shRNA silencing AAV

Name
AAV-m-PTGDS-shRNA

Cat No
shAAV-269734

Availability
Immediate

This is an AAV expressing shRNA for silencing of Mouse Ptgds.

shAAV-269734

AAV-m-PTGDS-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Ptgds (prostaglandin D2 synthase (brain)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

21kDa; L-PGDS; PGD2; PGDS; PGDS2; Ptgs3

Description (Vector)

Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.

Gene ID

19215

Gene Name (Vector)

prostaglandin D2 synthase (brain)

Gene Symbol

Ptgds

ORF Size (aa)

570

ORF Size (bp)

570 bp

RefSeq ID

NM_008963

RefSeq Synonyms

NM_008963, BC043015, BC038083,

Species

mouse

UniGene ID

Mm.1008

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.