mouse PPP1CA shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Ppp1ca.
shAAV-269184
AAV-m-PPP1CA-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Ppp1ca (protein phosphatase 1, catalytic subunit, alpha isoform). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
dism2; Ppp1c
Description (Vector)
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development.
Gene ID
19045
Gene Name (Vector)
protein phosphatase 1, catalytic subunit, alpha isoform
Gene Symbol
Ppp1ca
ORF Size (aa)
993
ORF Size (bp)
993 bp
RefSeq ID
NM_031868
RefSeq Synonyms
NM_031868, BC014828,
Species
mouse
UniGene ID
Mm.1970
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.