mouse PPARA shRNA silencing AAV

Name
AAV-m-PPARA-shRNA

Cat No
shAAV-269120

Availability
Immediate

This is an AAV expressing shRNA for silencing of Mouse Ppara.

shAAV-269120

AAV-m-PPARA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Ppara (peroxisome proliferator activated receptor alpha). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

4933429D07Rik; AW742785; Nr1c1; Ppar; PPAR-alpha; PPARalpha

Description (Vector)

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.

Gene ID

19013

Gene Name (Vector)

peroxisome proliferator activated receptor alpha

Gene Symbol

Ppara

ORF Size (aa)

1407

ORF Size (bp)

1407 bp

RefSeq ID

NM_011144

RefSeq Synonyms

NM_011144, NM_001113418, BC016892,

Species

mouse

UniGene ID

Mm.212789

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.