mouse PLXNA3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Plxna3.
shAAV-268916
AAV-m-PLXNA3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Plxna3 (plexin A3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
mKIAA4078; PlexA3; Plxa3; Plxn3; Plxn4; SEX
Description (Vector)
Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Gene ID
18846
Gene Name (Vector)
plexin A3
Gene Symbol
Plxna3
ORF Size (aa)
5388
ORF Size (bp)
5388 bp
RefSeq ID
NM_008883
RefSeq Synonyms
NM_008883, BC156397, BC093482,
Species
mouse
UniGene ID
Mm.1685
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.