human PLXNA3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PLXNA3.
shAAV-219252
AAV-h-PLXNA3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PLXNA3 (plexin A3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
6.3; HSSEXGENE; plexin-4; plexin-A3; PLXN3; PLXN4; semaphorin receptor SEX; Sex chromosome X transmembrane protein of HGF receptor family 3; XAP-6
Description (eCommerce)
Plexin-A3 is a coreceptor for SEMA3A and SEMA3F. It is necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plexin-A3 plays a role in axon guidance in the developing nervous system. It regulates the migration of sympathetic neurons, but not of neural crest precursors. Plexin-A3 is required for normal dendrite spine morphology in pyramidal neurons. It may play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P51805].
Description (Vector)
PLXNA3 is a member of the plexin class of proteins. The encoded protein is a transmembrane protein that is exposed on the cell surface. This gene is thought to be involved in epithelial and neural tissue development.
Gene ID
55558
Gene Name (eCommerce)
plexin A3
Gene Name (Vector)
plexin A3
Gene Symbol
PLXNA3
HGNC ID
HGNC:9101
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5616
ORF Size (bp)
5616 bp
Protein Name (eCommerce)
Plexin-A3
RefSeq ID
NM_017514
RefSeq Synonyms
NM_017514, BC172494, BC156373,
Research Areas
Axon Guidance,Cytoskeleton,Neurobiology,Neurodevelopment,Signal Transduction
Research Areas (Faceted)
signal_transduction,neurobiology,cell_biology,developmental_biology
Species
human
Target Sentence
Plexin-A3 is a coreceptor for SEMA3A and SEMA3F. It is necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plexin-A3 plays a role in axon guidance in the developing nervous system. It regulates the migration of sympathetic neurons, but not of neural crest precursors. Plexin-A3 is required for normal dendrite spine morphology in pyramidal neurons. It may play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P51805].
UniGene ID
Hs.632839
UniProt ID (eCommerce)
P51805
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.