mouse P4HB shRNA silencing AAV

Name
AAV-m-P4HB-shRNA

Cat No
shAAV-267965

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse P4hb.

shAAV-267965

AAV-m-P4HB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse P4hb (prolyl 4-hydroxylase, beta polypeptide). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ERp59; PDI; Pdia1; Thbp

Description (Vector)

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP.

Gene ID

18453

Gene Name (Vector)

prolyl 4-hydroxylase, beta polypeptide

Gene Symbol

P4hb

ORF Size (aa)

1530

ORF Size (bp)

1530 bp

RefSeq ID

NM_011032

RefSeq Synonyms

NM_011032, BC093512, BC008549,

Species

mouse

UniGene ID

Mm.475301

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.