mouse OAS3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Oas3.
shAAV-266356
AAV-m-OAS3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Oas3 (2′-5′ oligoadenylate synthetase 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Oasl10
Description (Vector)
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
Gene ID
246727
Gene Name (Vector)
2'-5' oligoadenylate synthetase 3
Gene Symbol
Oas3
ORF Size (aa)
3417
ORF Size (bp)
3417 bp
RefSeq ID
NM_145226
RefSeq Synonyms
NM_145226, BC141055,
Species
mouse
UniGene ID
Mm.204887
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.