human OLIG2 shRNA silencing AAV

Name
AAV-h-OLIG2-shRNA

Cat No
shAAV-217410

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human OLIG2.

shAAV-217410

AAV-h-OLIG2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human OLIG2 (oligodendrocyte lineage transcription factor 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BHLHB1; bHLHe19; OLIGO2; PRKCBP2; RACK17

Description (Vector)

OLIG2 encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.

Gene ID

10215

Gene Name (Vector)

oligodendrocyte lineage transcription factor 2

Gene Symbol

OLIG2

HGNC ID

HGNC:9398

ORF Size (aa)

972

ORF Size (bp)

972 bp

RefSeq ID

NM_005806

RefSeq Synonyms

NM_005806, BC047511, BC036245,

Species

human

UniGene ID

Hs.176977

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.