mouse NR1I2 shRNA silencing AAV

Name
AAV-m-NR1I2-shRNA

Cat No
shAAV-266039

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Nr1i2.

shAAV-266039

AAV-m-NR1I2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Nr1i2 (nuclear receptor subfamily 1, group I, member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

mPXR; PXR; PXR.1; PXR.2; PXR1; SXR

Description (Vector)

Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.

Gene ID

18171

Gene Name (Vector)

nuclear receptor subfamily 1, group I, member 2

Gene Symbol

Nr1i2

ORF Size (aa)

1296

ORF Size (bp)

1296 bp

RefSeq ID

NM_010936

RefSeq Synonyms

NM_010936, NM_001098404, BC137780, BC120796,

Species

mouse

UniGene ID

Mm.8509

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.