mouse NLRP6 shRNA silencing AAV

Name 
AAV-m-NLRP6-shRNA
Cat No 
shAAV-265861
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Mouse NLRP6.

shAAV-265861
AAV-m-NLRP6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse NLRP6 (NLR family, pyrin domain containing 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AI504961; Nalp6; Navr/Avr; Pypaf5;
Description (Vector)
NLRP6 may contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Binds arginine-vasopressin but not angiotensin II and acts as an arginine-vasopressin V2 receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation (By similarity).
Gene ID
101613
Gene Name (Vector)
NLR family, pyrin domain containing 6
Gene Symbol
NLRP6
ORF Size (aa)
1341
ORF Size (bp)
1341 bp
RefSeq ID
NM_133946
RefSeq Synonyms
NM_133946, NM_001081389, BC031139,
Species
mouse
UniGene ID
Mm.386833

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.