mouse NFIL3 shRNA silencing AAV

Name
AAV-m-NFIL3-shRNA

Cat No
shAAV-265719

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Nfil3.

shAAV-265719

AAV-m-NFIL3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Nfil3 (nuclear factor, interleukin 3, regulated). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

AV225605; E4BP4

Description (Vector)

Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity).

Gene ID

18030

Gene Name (Vector)

nuclear factor, interleukin 3, regulated

Gene Symbol

Nfil3

ORF Size (aa)

1389

ORF Size (bp)

1389 bp

RefSeq ID

NM_017373

RefSeq Synonyms

NM_017373, BC100384, BC031377,

Species

mouse

UniGene ID

Mm.136604

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.