mouse NEIL3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Neil3.
shAAV-265640
AAV-m-NEIL3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Neil3 (nei like 3 (E. coli)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI449477; BC034753; C85903
Description (Vector)
Reports about DNA glycosylase activity are contradictory. A number of references report finding no DNA glycosylase activity and the protein lacks a proline residue at the N-terminus which functions as an active site residue in other members of the FPG family. However, the mouse ortholog has been shown to have both DNA glycosylase and AP lyase activities and PubMed:19170771 demonstrates AP lyase activity. Prefers single-stranded DNA or partially single-stranded DNA structures such as bubble and fork structures to double-stranded DNA in vitro. Displays a broad recognition spectrum, preferring FapyA and FapyG followed by 5-OHU, 5-PHC and 5-OHMH and then Tg and 8-oxoA. No activity on 8-oxoG detected.
Gene ID
234258
Gene Name (Vector)
nei like 3 (E. coli)
Gene Symbol
Neil3
ORF Size (aa)
1821
ORF Size (bp)
1821 bp
RefSeq ID
NM_146208
RefSeq Synonyms
NM_146208, BC034753, BC024921,
Species
mouse
UniGene ID
Mm.281749
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.