mouse MTDH shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Mtdh.
shAAV-265115
AAV-m-MTDH-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Mtdh (metadherin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2610103J23Rik; 3D3; 3D3/Lyric; AEG-1; AV353288; D8Bwg1112e; Lyric
Description (Vector)
Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance.
Gene ID
67154
Gene Name (Vector)
metadherin
Gene Symbol
Mtdh
ORF Size (aa)
1740
ORF Size (bp)
1740 bp
RefSeq ID
NM_026002
RefSeq Synonyms
NM_026002, BC138859, BC138858,
Species
mouse
UniGene ID
Mm.130883
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.