mouse MRGPRX1 shRNA silencing AAV

Name
AAV-m-MRGPRX1-shRNA

Cat No
shAAV-264893

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Mouse Mrgprx1.

shAAV-264893

AAV-m-MRGPRX1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Mrgprx1 (MAS-related GPR, member X1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MrgC11; Mrgprc11

Description (Vector)

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in an histamine-independent manner.

Gene ID

404242

Gene Name (Vector)

MAS-related GPR, member X1

Gene Symbol

Mrgprx1

ORF Size (aa)

972

ORF Size (bp)

972 bp

RefSeq ID

NM_207540

RefSeq Synonyms

NM_207540, BC150669,

Species

mouse

UniGene ID

Mm.354955

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.