mouse MKNK2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Mknk2.
shAAV-264675
AAV-m-MKNK2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Mknk2 (MAP kinase-interacting serine/threonine kinase 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2010016G11Rik; Gprk7; Mnk2
Description (Vector)
Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.
Gene ID
17347
Gene Name (Vector)
MAP kinase-interacting serine/threonine kinase 2
Gene Symbol
Mknk2
ORF Size (aa)
1239
ORF Size (bp)
1239 bp
RefSeq ID
NM_021462
RefSeq Synonyms
NM_021462, BC010256,
Species
mouse
UniGene ID
Mm.472174
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.