mouse MEMO1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Memo1.
shAAV-264492
AAV-m-MEMO1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Memo1 (mediator of cell motility 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
0610016J10Rik; D930048L02Rik
Description (Vector)
MEMO1 may control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.
Gene ID
76890
Gene Name (Vector)
mediator of cell motility 1
Gene Symbol
Memo1
ORF Size (aa)
894
ORF Size (bp)
894 bp
RefSeq ID
NM_133771
RefSeq Synonyms
NM_133771, BC013819,
Species
mouse
UniGene ID
Mm.311874
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.