mouse MARCH1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse March1.
shAAV-264248
AAV-m-MARCH1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse March1 (membrane-associated ring finger (C3HC4) 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2900024D24Rik; BB085186
Description (Vector)
E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.
Gene ID
72925
Gene Name (Vector)
membrane-associated ring finger (C3HC4) 1
Gene Symbol
1-Mar
ORF Size (aa)
858
ORF Size (bp)
858 bp
RefSeq ID
NM_175188
RefSeq Synonyms
NM_175188, NM_001293784, NM_001166375, NM_001166372, BC066008,
Species
mouse
UniGene ID
Mm.380457
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.