mouse LRWD1 shRNA silencing AAV

Name
AAV-m-LRWD1-shRNA

Cat No
shAAV-263918

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Mouse Lrwd1.

shAAV-263918

AAV-m-LRWD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Mouse Lrwd1 (leucine-rich repeats and WD repeat domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

1200011O22Rik; AU042569; AW548074; Orca

Description (Vector)

Associated component of the origin recognition complex (ORC) required to recruit and stabilize the ORC complex to chromatin. Probably required for the association of ORC on chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin: binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. It is unclear whether it recongnizes and binds these repressive marks by itself or needs additional factors.

Gene ID

71735

Gene Name (Vector)

leucine-rich repeats and WD repeat domain containing 1

Gene Symbol

Lrwd1

ORF Size (aa)

1947

ORF Size (bp)

1947 bp

RefSeq ID

NM_027891

RefSeq Synonyms

NM_027891, BC048397,

Species

mouse

UniGene ID

Mm.425292

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.